2,6-Quinolinyl derivatives as potent VLA-4 antagonists

Bioorg Med Chem Lett. 2007 Jan 1;17(1):142-6. doi: 10.1016/j.bmcl.2006.09.069. Epub 2006 Oct 10.

Abstract

A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Humans
  • Integrin alpha4beta1 / antagonists & inhibitors*
  • Quinolines / chemistry*
  • Quinolines / pharmacology
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Integrin alpha4beta1
  • Quinolines